Download Bioterrorism - A Medical Dictionary, Bibliography, and by Health Publica Icon Health Publications PDF

By Health Publica Icon Health Publications

It is a 3-in-1 reference e-book. It offers an entire clinical dictionary overlaying countless numbers of phrases and expressions in terms of bioterrorism. It additionally offers vast lists of bibliographic citations. ultimately, it presents details to clients on how you can replace their wisdom utilizing a number of web assets. The booklet is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with learn devoted to bioterrorism. in case your time is effective, this booklet is for you. First, you won't waste time looking out the web whereas lacking loads of correct info. moment, the publication additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing 1000's of websites.

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Additional info for Bioterrorism - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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Modern, more contained epidemics are common in South America and Madagascar. In addition, Y. pestis is a category A bioterrorism agent with natural zoonotic foci as readily available sources of the organism on nearly every continent. The ability of pathogens to acquire iron from their hosts is one critical parameter in the outcome of the infectious process. Y. pestis encodes nine potential inorganic iron transport systems and two heme/hemoprotein transport systems. Of these, the siderophore-dependent yersiniabactin (Ybt) iron transport system and the Yfe ABC transporter are the most important systems for acquisition of inorganic iron.

In addition, the Ybt system is activated by an AraC-type regulator, YbtA, possibly acting in concert with the Ybt siderophore. The Yfe system is also repressed by excess manganese through the Fur protein. In vivo repression by manganese and Fur is a unique regulatory mechanism. The specific aims of this proposal are to continue characterizing genetic and biochemical aspects of 1) the Ybt and 2) the Yfe transport systems and 3) to analyze the expression of these two systems in vivo and determine their roles in systemic spread of the disease.

Both have also been associated with the immune responses to viruses. Using transfected cell lines and available knockout mice the mechanism by which these proteins affect both initial induction of cytokines as well as the subsequent immune responses to LCMV and Ebola virus will be defined. The specific TLRs (and other "pattern recognition proteins") involved in these responses as well as their interactions will be studied. The effect of these early recognition events on long-term Band T cell immunity will be investigated.

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